{"id":1141,"date":"2016-07-17T01:57:00","date_gmt":"2016-07-16T16:57:00","guid":{"rendered":"http:\/\/kawasaki-gim4.main.jp\/wp-gim4web\/?p=1141"},"modified":"2016-07-17T01:57:00","modified_gmt":"2016-07-16T16:57:00","slug":"dr-sequist","status":"publish","type":"post","link":"https:\/\/kawasaki-gim4.main.jp\/?p=1141","title":{"rendered":"Dr. Sequist"},"content":{"rendered":"<p>\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u306e\u6709\u540d\u4ebaDr. Sequist\u304c\u571f\u66dc\u65e5\u306b\u5ca1\u5c71\u3067\u8b1b\u6f14\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305a\u9a5a\u3044\u305f\u306e\u306f\u300114\u5e74\u9593\u30b2\u30d5\u30a3\u30c1\u30cb\u30d6\u3092\u6295\u4e0e\u3057\u3066\u3044\u308b\u3054\u81ea\u8eab\u306e\u60a3\u8005\u3055\u3093\u306e\u8a71\u3067\u3057\u305f\u3002\u304d\u3063\u3068\u3053\u306e\u65b9\u306f\u7d14\u7c8b\u306aEGFR oncogene\u3067\u767a\u764c\u3057\u3066\u304a\u308a\u4ed6\u306emutation burden\u306f\u6975\u3081\u3066\u5c11\u306a\u304f\u3001alternative pathway\u3082\u5165\u308a\u306b\u304f\u3044\u306e\u3067\u306f\u3068\u601d\u3044\u307e\u3057\u305f\u3002rociletinib\u306e\u526f\u4f5c\u7528\u306e\u9ad8\u8840\u7cd6\u306f\u3001\u4e3b\u306b\u4ee3\u8b1d\u7269\u304cIGF-1R\u3068insulin receptor kinase\u3092\u6291\u5236\u3059\u308b\u304b\u3089\u3067\u306f\u3068\u306e\u3053\u3068\u3067\u3057\u305f\u3002IGF\/IGF-1R\u4ea2\u9032\u306f\u8010\u6027\u6a5f\u5e8f\u306e\u4e00\u3064\u3067\u3001\u3053\u308c\u3092\u6291\u5236\u3059\u308b\u3068\u672c\u6765\u306fPFS\u306f\u9577\u304f\u306a\u308b\u306f\u305a\u3067\u3059\u304c\u3001rociletinib\u306e\u594f\u52b9\u671f\u9593\u306f\u77ed\u3044\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002IGF-1R\u3092\u6291\u5236\u3059\u308b\u3068feedback\u304c\u304b\u304b\u308ainsulin\u306e\u5206\u6ccc\u306f\u4ea2\u9032\u3057\u3066\u4f4e\u8840\u7cd6\u306b\u306a\u308a\u305d\u3046\u306a\u6c17\u304c\u3057\u307e\u3057\u305f\u304c\u3001\u53d7\u5bb9\u4f53\u304c\u50cd\u304b\u306a\u3044\u306e\u3067\u9ad8\u8840\u7cd6\u306b\u306a\u308b\u3088\u3046\u3067\u3059\u3002\u8c4a\u5ca1\u5148\u751f\u304c\u3053\u306e\u3042\u305f\u308a\u3092\u8cea\u554f\u3057\u3066\u3044\u307e\u3057\u305f\u3002osimertinib\u3068\u306e\u6709\u671b\u306acombination\u3067\u306f\u3001BCL2\u963b\u5bb3\u5264\u3068\u306ecombi\u3067SCLC\u306e\u79fb\u884c\u304c\u963b\u6b62\u3055\u308c\u308b\u306e\u3067\u306f\u3068\u8a71\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u30d1\u30cd\u30ea\u30b9\u30c8\u306e\u5e02\u539f\u5148\u751f\u306fbevacizumab\u3068\u306ecombi\u3092\u3001\u6728\u6d66\u5148\u751f\u306fCBDCA+PTX+gefitinib\u306eCR10%\u304b\u3089chemo\u3068\u306ecombi\u306b\u8208\u5473\u3092\u3082\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3042\u3068\u3001Dr. Sequist\u306e\u30eb\u30fc\u30c4\uff08\uff14\u4e16\u4ee3\u524d\uff09\u306f\u65e5\u672c\u3068\u306e\u3053\u3068\u3067\u9a5a\u304d\u307e\u3057\u305f\u3002\u660e\u6cbb\u6642\u4ee3\u306b\u7c73\u56fd\u306b\u884c\u304b\u308c\u305f\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u521d\u3081\u3066\u306e\u6765\u65e5\u3068\u306e\u3053\u3068\u3067\u3059\u304c\u3001 \u512a\u3057\u3044\u4eba\u67c4\u3067\u308f\u304b\u308a\u3084\u3059\u3044\u82f1\u8a9e\u3092\u8a71\u3057\u3066\u304f\u308c\u307e\u3057\u305f\u3002\u305c\u3072\u307e\u305f\u6765\u3066\u6b32\u3057\u3044\u3067\u3059\u3002<\/p>\n<p><img decoding=\"async\" alt=\"Dr. Sequist\uff11\" class=\"pict\" height=\"104\" src=\"http:\/\/img-cdn.jg.jugem.jp\/0db\/2419030\/20160716_4467196.jpg\" width=\"139\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u306e\u6709\u540d\u4ebaDr. Sequist\u304c\u571f\u66dc\u65e5\u306b\u5ca1\u5c71\u3067\u8b1b\u6f14\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305a\u9a5a\u3044\u305f\u306e\u306f\u300114\u5e74\u9593\u30b2\u30d5\u30a3\u30c1\u30cb\u30d6\u3092\u6295\u4e0e\u3057\u3066\u3044\u308b\u3054\u81ea\u8eab\u306e\u60a3\u8005\u3055\u3093\u306e\u8a71\u3067\u3057\u305f\u3002\u304d\u3063\u3068\u3053\u306e\u65b9\u306f\u7d14\u7c8b\u306aEGFR oncogene\u3067\u767a\u764c\u3057\u3066\u304a\u308a\u4ed6\u306em [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2281,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","footnotes":""},"categories":[10],"tags":[],"class_list":["post-1141","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-10"],"_links":{"self":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/1141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1141"}],"version-history":[{"count":0,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/1141\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/media\/2281"}],"wp:attachment":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}