{"id":1188,"date":"2016-09-19T08:59:00","date_gmt":"2016-09-18T23:59:00","guid":{"rendered":"http:\/\/kawasaki-gim4.main.jp\/wp-gim4web\/?p=1188"},"modified":"2016-09-19T08:59:00","modified_gmt":"2016-09-18T23:59:00","slug":"braf-v600e%e3%81%ae%e3%83%a2%e3%83%8e%e3%83%9e%e3%83%bc%e3%81%a8%e3%83%80%e3%82%a4%e3%83%9e%e3%83%bc","status":"publish","type":"post","link":"https:\/\/kawasaki-gim4.main.jp\/?p=1188","title":{"rendered":"BRAF V600E\u306e\u30e2\u30ce\u30de\u30fc\u3068\u30c0\u30a4\u30de\u30fc"},"content":{"rendered":"<p>\u5148\u9031\u306e\u6284\u8aad\u4f1a\u306f\u78ef\u5d0e\u5148\u751f\u304c\u300cBRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition. Cancer Cell. 2015;28(3):370-83\u300d\u3092\u6284\u8aad\u3057\u3066\u304f\u308c\u307e\u3057\u305f\u3002\u60aa\u6027\u9ed2\u8272\u816b\u306e\u4e3b\u30b7\u30b0\u30ca\u30eb\u306eERK-&gt;RAS-&gt;RAF\u306f\u80ba\u764c\u3067\u3082\u540c\u3058\u4f1d\u9054\u7d4c\u8def\u3067\u3059\u304c\u3001\u9055\u3044\u306f\u3088\u304f\u77e5\u3089\u306a\u304b\u3063\u305f\u3067\u3059\u3002BRAF V600E\u306fRAS\u6d3b\u6027\u304c\u5c11\u306a\u3044\u6642\u306bactivated monomar\u3068\u3057\u3066\u30b7\u30b0\u30ca\u30eb\u3092\u9001\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u3067\u3059\u3002RAF\u963b\u5bb3\u5264\u306evemurafenib\u306fV600E\u306emonomer\u306e\u307f\u306b\u52b9\u679c\u3092\u6709\u3057\u3066\u304a\u308a\u3001dimer\u306b\u306f\u52b9\u304b\u306a\u3044\u3068\u306e\u3053\u3068\u3067\u3057\u305f\u3002dimer\u306e\u7247\u65b9\u306b\u304f\u3063\u3064\u304f\u3068\u4ed6\u65b9\u306b\u306f\u89aa\u548c\u6027\u304c\u306a\u304f\u306a\u308a\u5236\u5fa1\u3067\u304d\u306a\u3044\u304b\u3089\u306e\u3088\u3046\u3067\u3059\u3002\u60aa\u6027\u9ed2\u8272\u816b\u306f\u514d\u75ab\u7cfb\u306f\u52c9\u5f37\u305b\u3056\u308b\u5f97\u305a\u5c11\u3057\u305a\u3064\u304b\u3058\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u30b7\u30b0\u30ca\u30eb\u306b\u3064\u3044\u3066\u3082\u5965\u304c\u6df1\u305d\u3046\u3067\u3057\u305f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5148\u9031\u306e\u6284\u8aad\u4f1a\u306f\u78ef\u5d0e\u5148\u751f\u304c\u300cBRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivit [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2288,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-1188","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/1188","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1188"}],"version-history":[{"count":0,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/1188\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/media\/2288"}],"wp:attachment":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1188"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1188"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1188"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}