{"id":1217,"date":"2016-10-19T00:23:00","date_gmt":"2016-10-18T15:23:00","guid":{"rendered":"http:\/\/kawasaki-gim4.main.jp\/wp-gim4web\/?p=1217"},"modified":"2016-10-19T00:23:00","modified_gmt":"2016-10-18T15:23:00","slug":"mtor%e9%98%bb%e5%ae%b3%e5%89%a4","status":"publish","type":"post","link":"https:\/\/kawasaki-gim4.main.jp\/?p=1217","title":{"rendered":"mTOR\u963b\u5bb3\u5264"},"content":{"rendered":"<p>\u4eca\u9031\u306eSunday meeting\u3067\u306f\u3001\u7dcf\u5408\u5916\u79d1\u306e\u5927\u5b66\u9662\uff14\u5e74\u751f\u306e\u77f3\u7530\u5148\u751f\u304c\u300cOvercoming mTOR resistance mutations with a new-generation mTOR inhibitor. Nature. 2016;534(7606): 272-6. \u300d\u3092\u6284\u8aad\u3057\u307e\u3057\u305f\u3002\u7b2c\uff11\u4e16\u4ee3\u306emTOR\u963b\u5bb3\u5264\uff08\u30e9\u30d1\u30de\u30a4\u30b7\u30f3\u3001\u30a8\u30d9\u30ed\u30ea\u30e0\u30b9\uff09\u3001\u7b2c\uff12\u4e16\u4ee3\u306emTOR\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\uff08AZD8055\uff09\u8010\u6027\u306e\u8a71\u3067\u3057\u305f\u3002AZD8055\u306b\u5bfe\u3059\u308b\u8010\u6027\u6a5f\u69cb\u306f\u3001\u30ad\u30ca\u30fc\u30bc\u6d3b\u6027\u90e8\u4f4d\u306e\u5909\u7570\u306b\u3088\u308b\u30ad\u30ca\u30fc\u30bc\u6d3b\u6027\u306e\u4e0a\u6607\u306e\u305f\u3081\u3067\u3057\u305f\u3002\u4e21\u85ac\u5264\u306e\u8010\u6027\u3092\u514b\u670d\u3059\u308b\u305f\u3081\u306b\u30012\u3064\u306e\u85ac\u5264\u7d50\u5408\u30dd\u30b1\u30c3\u30c8\uff08FRB\u3068\u30ad\u30ca\u30fc\u30bc\u30c9\u30e1\u30a4\u30f3\uff09\u3092\u7e4b\u3052\u308b\u85ac\u5264\uff08RapaLink-1)\u3092\u8003\u6848\u3057\u3001\u4e73\u764c\u7d30\u80de\u682a\u3092\u4f7f\u7528\u3057\u305fin vitro\u3001in vivo\u306e\u4e21\u65b9\u3067\u8010\u6027\u89e3\u9664\u3092\u8a3c\u660e\u3057\u3066\u3044\u307e\u3057\u305f\u3002AZD8055\u306fmTORC1\u3068mTORC2\u306e\u4e21\u8005\u3092\u963b\u5bb3\u3059\u308bhopeful\u306a\u85ac\u5264\u3068\u3057\u3066\u5ddd\u5d0e\u306b\u6765\u305f\u9803\u304b\u3089\u80ba\u764c\u8010\u6027\u682a\u3092\u4f5c\u3063\u305f\u308a\u4f75\u7528\u52b9\u679c\u3092\u307f\u3066\u3044\u307e\u3057\u305f\u3002\u6b8b\u5ff5\u306a\u304c\u3089\u80ba\u764c\u306b\u306f\u4f7f\u7528\u3055\u308c\u306a\u3044\u3088\u3046\u3067\u7720\u3063\u305f\u307e\u307e\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u30a8\u30d9\u30ed\u30ea\u30e0\u30b9\u306e\u6709\u52b9\u6027\u304c\u8a3c\u660e\u3055\u308c\u305f\u4e73\u764c\u3067\u306f\u304b\u306a\u308a\u9762\u767d\u3044\u3088\u3046\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u9031\u306eSunday meeting\u3067\u306f\u3001\u7dcf\u5408\u5916\u79d1\u306e\u5927\u5b66\u9662\uff14\u5e74\u751f\u306e\u77f3\u7530\u5148\u751f\u304c\u300cOvercoming mTOR resistance mutations with a new-generation mTOR inhibito [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2280,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","footnotes":""},"categories":[11],"tags":[],"class_list":["post-1217","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-journal-club"],"_links":{"self":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/1217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1217"}],"version-history":[{"count":0,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/1217\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/media\/2280"}],"wp:attachment":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}