{"id":1256,"date":"2016-12-04T00:22:00","date_gmt":"2016-12-03T15:22:00","guid":{"rendered":"http:\/\/kawasaki-gim4.main.jp\/wp-gim4web\/?p=1256"},"modified":"2016-12-04T00:22:00","modified_gmt":"2016-12-03T15:22:00","slug":"egfr%e5%a4%89%e7%95%b0%e3%81%a8pd-1","status":"publish","type":"post","link":"https:\/\/kawasaki-gim4.main.jp\/?p=1256","title":{"rendered":"EGFR\u5909\u7570\u3068PD-1"},"content":{"rendered":"<p>\u78ef\u5d0e\u5148\u751f\u304c\u300cActivation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 2013;3:1355-63.\u300d\u3092\u6284\u8aad\u3057\u307e\u3057\u305f\u3002\u3082\u3046\uff13\u5e74\u524d\u306b\u306a\u308a\u307e\u3059\u304c\u3001EGFR\u5909\u7570\u3068PD-1\u306e\u95a2\u9023\u3092\u8a73\u3057\u304f\u8a18\u3057\u305f\u4ee3\u8868\u7684\u306a\u8ad6\u6587\u3067\u3059\u3002EGFR\u5909\u7570\u306fPD-1\u3001PD-L1\u3084CTLA-4\u306a\u3069\u306e\u514d\u75ab\u6291\u5236\u7cfb\u306b\u50cd\u304f\u5206\u5b50\u3092upregulate\u3057\u3001CTL\u3092\u6e1b\u5c11\u3055\u305bTreg\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3067\u793a\u3057\u3066\u3044\u307e\u3057\u305f\u3002PD-1\u6297\u4f53\u306fEGFR\u5909\u7570\u30de\u30a6\u30b9\u306e\u751f\u5b58\u3092\u5ef6\u9577\u3059\u308b\u3053\u3068\u304b\u3089\u3001EGFR-TKI followed by PD-1 antibody\u3068\u3044\u3046strategy\u304c\u751f\u307e\u308c\u307e\u3057\u305f\u3002\u5b9f\u969b\u306b\u306fEGFR\u5909\u7570\u306b\u306f\u52b9\u679c\u304c\u4e4f\u3057\u305d\u3046\u3068\u3044\u3046\u306e\u304c\u3053\u308c\u307e\u3067\u306eretro\u306e\u89e3\u6790\u3067\u3059\u3002EGFR\u3084ALK\u80ba\u764c\u3067selection\u3092\u304b\u3051\u305f\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u5f85\u3061\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u78ef\u5d0e\u5148\u751f\u304c\u300cActivation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 2 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2280,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","footnotes":""},"categories":[11],"tags":[],"class_list":["post-1256","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-journal-club"],"_links":{"self":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/1256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1256"}],"version-history":[{"count":0,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/1256\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/media\/2280"}],"wp:attachment":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1256"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1256"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}