{"id":770,"date":"2015-06-10T00:17:00","date_gmt":"2015-06-09T15:17:00","guid":{"rendered":"http:\/\/kawasaki-gim4.main.jp\/wp-gim4web\/?p=770"},"modified":"2015-06-10T00:17:00","modified_gmt":"2015-06-09T15:17:00","slug":"%e3%82%b9%e3%83%bc%e3%83%91%e3%83%bc%e3%82%a8%e3%83%b3%e3%83%8f%e3%83%b3%e3%82%b5%e3%83%bc","status":"publish","type":"post","link":"https:\/\/kawasaki-gim4.main.jp\/?p=770","title":{"rendered":"\u30b9\u30fc\u30d1\u30fc\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc"},"content":{"rendered":"<p>Sundey meeting\u3067\u3001\u6df1\u6fa4\u5148\u751f\u304c\u300cAn oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science. 2014 Dec 12;346(6215):1373-7. \u300d\u3092\u6284\u8aad\u3057\u3066\u304f\u308c\u307e\u3057\u305f\u3002\u6065\u305a\u304b\u3057\u306a\u304c\u3089\u3001super-enhancer\u3068\u3044\u3046\u8a00\u8449\u81ea\u4f53\u3092\u77e5\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u300cCancer. Cancer by super-enhancer. Science. 2014 Dec 12;346(6215):1291-2.\u300d\u3082\u308f\u304b\u308a\u3084\u3059\u304f\u89e3\u8aac\u3057\u3066\u304f\u308c\u307e\u3057\u305f\u3002T\u7d30\u80de\u306e\u6025\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\u306b\u304a\u3044\u3066\u3001small insertion\u306b\u3088\u308anon-coding RNA\u306emutation\u304c\u8d77\u3053\u308a\u307e\u3059\u3002\u3053\u308c\u304cTAL1 oncogene\u306e\u767a\u73fe\u3092\u5897\u5f37\u3059\u308b\u8ee2\u5199\u56e0\u5b50MYB \u3068\u4ed6\u306e\u5206\u5b50\u3068\u306e\u7d50\u5408\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002super-enhancer\u3068\u3044\u3046\u306e\u306f\u3001ChIP-seq\u6cd5\u306b\u3088\u3063\u3066\u8a3c\u660e\u3055\u308c\u305f\u3001\u8fd1\u63a5\u3057\u305f\u30b2\u30ce\u30e0\u4e0a\u3067\u3053\u306e\u3088\u3046\u306a\u591a\u6570\u306e\u8abf\u7bc0\u56e0\u5b50\u304c\u7d50\u5408\u3057\u3066\u3044\u308benhancer\u306e\u3053\u3068\u3067\u3057\u305f\uff08What are super-enhancers? Nat Genet. 2015;47:8-12.\uff09\u3002\u4eca\u5f8c\u3001\u80ba\u764c\u5206\u91ce\u3067\u3082\u767a\u764c\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059non-coding RNA\u306emutation\u304c\u3067\u3066\u304f\u308b\u306e\u3067\u3057\u3087\u3046\u306d\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sundey meeting\u3067\u3001\u6df1\u6fa4\u5148\u751f\u304c\u300cAn oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic el [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2287,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","footnotes":""},"categories":[14],"tags":[],"class_list":["post-770","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-14"],"_links":{"self":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/770","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=770"}],"version-history":[{"count":0,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/770\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/media\/2287"}],"wp:attachment":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=770"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=770"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}