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\n\u6b21\u306f\u77e2\u91ce\u5148\u751f\u304c\u3001EGFR-TKI\u8010\u6027\u306e\u8a71\u3092\u3057\u3066\u304f\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u3063\u3068\u6d41\u3057\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u3001MET exon14\u306eskip mutation\u306e\u3053\u3068\u3092\u8a00\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u79c1\u306f\u77e5\u3089\u306a\u304b\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u300cActivation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. Cancer Discov. 2015 May 13\u300d\u306b\u80ba\u817a\u764c\u306e3\uff05\u3068\u51fa\u3066\u3044\u307e\u3057\u305f\u3002BIM\u6b20\u5931\u591a\u578b\u306fEGFR\u5909\u7570\u80ba\u764c\u306eEGFR-TKI\u8010\u6027\u3068\u76f8\u95a2\u3059\u308b\u304c\u3001CML\u3084HCC\u306b\u5bfe\u3059\u308bTKI\u306e\u52b9\u679c\u3068\u306f\u7121\u95a2\u4fc2\u3068\u3044\u3046\u30e1\u30bf\u89e3\u6790\u3082\u8aac\u660e\u3057\u3066\u304f\u308c\u307e\u3057\u305f\u3002\u300cThe effect of BIM deletion polymorphism on intrinsic resistance and clinical outcome of cancer patient with kinase inhibitor therapy. Sci Rep. 2015 Jun 15;5:11348.\u300d\u3067\u3059\u3002\u307e\u305f\u3001\u540c\u9580\u306e\u5c3e\u702c\u5148\u751f\u3084\u677e\u5c3e\u6075\u592a\u90ce\u5148\u751f\u3068\u5171\u540c\u7814\u7a76\u3067\u3001BIM\u591a\u578b\u304c\u80ba\u764c\u306e\u30ea\u30b9\u30af\u306b\u306a\u308b\u304b\u3069\u3046\u304b\u3092EGFR\u5909\u7570\u3068\u91ce\u751f\u578b\u306b\u5206\u3051\u3066\u8abf\u3079\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u7d50\u5c40\u306f\u7121\u95a2\u4fc2\u3068\u306e\u3053\u3068\u3067\u3057\u305f\u3002\u300cLack of association between the BIM deletion polymorphism and the risk of lung cancer with and without EGFR mutations. J Thorac Oncol. 2015 Jan;10(1):59-66.\u300d\u3067\u3059\u3002\u3055\u3059\u304c\u77e2\u91ce\u5148\u751f\u3067\u3001\u3053\u308c\u3089\u9818\u57df\u306e\u6700\u5148\u7aef\u7814\u7a76\u3068follow\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
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