{"id":807,"date":"2015-07-18T00:38:00","date_gmt":"2015-07-17T15:38:00","guid":{"rendered":"http:\/\/kawasaki-gim4.main.jp\/wp-gim4web\/?p=807"},"modified":"2015-07-18T00:38:00","modified_gmt":"2015-07-17T15:38:00","slug":"jsmo-day-2","status":"publish","type":"post","link":"https:\/\/kawasaki-gim4.main.jp\/?p=807","title":{"rendered":"JSMO day 2"},"content":{"rendered":"<p>2\u65e5\u76ee\u306eJSMO\u3067\u3059\u3002\u671d\u4e00\u306e\u300c\u4eba\u3092\u5bfe\u8c61\u3068\u3059\u308b\u533b\u5b66\u7814\u7a76\u306b\u5bfe\u3059\u308b\u502b\u7406\u6307\u91dd\u300d\u306e\u6559\u80b2\u8b1b\u6f14\u3092\u805e\u304d\u307e\u3057\u305f\u3002\u9662\u5185\u3060\u3051\u306eretrospective\u306adata\u89e3\u6790\u3082IRB\u306b\u51fa\u3055\u306a\u304f\u3066\u306f\u3044\u3051\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u304c\u3088\u304f\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u6b21\u306f\u3001\u5c71\u6839\u5148\u751f\u306eCancer Survivirship\u306e\u6559\u80b2\u8b1b\u6f14\u3067\u3057\u305f\u3002\u975e\u5e38\u306b\u308f\u304b\u308a\u3084\u3059\u3044\u3068\u597d\u8a55\u3067\u3057\u305f\u3002\u305d\u306e\u5f8c\u306fESMO\/JSMO\u306e\u5408\u540c\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3067immunocheckpoit blockade in cancer therapy\u306e\u8b1b\u6f14\u3067\u3057\u305f\u3002\u7389\u7530\u5148\u751f\u306f\u3001PD-L1\/CD80\u6297\u4f5343H12\u306b\u3064\u3044\u3066\u306e\u8a71\u3067\u3057\u305f\u3002antigen presenting cell\/tumor cell\u306ePD-L1\u3068T cell\u306eCD80\uff08B7-1\uff09\u3092block\u3059\u308b\u3068exhausted T cell\u304c\u518d\u6d3b\u6027\u5316\u3057\u3001CD80\u306fexhaustion marker\u3068\u3057\u3066\u4f7f\u3048\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u3002Dr. Haanen\u306f\u5206\u96e2\u3057\u305f\u816b\u760d\u304b\u3089\u816b\u760d\u7279\u7570\u6027\u6297\u539f\u306e\u540c\u5b9a\u3084\u3001neo-antigen specific TCR+\u306e\u8a71\u3092\u3055\u308c\u307e\u3057\u305f\u3002\u5317\u91ce\u5148\u751f\u306f\u3001\u6297CTLA4\u6297\u4f53\uff0b\u653e\u5c04\u7dda\u306b\u3088\u308babscopal effect\uff08\u653e\u5c04\u7dda\u7167\u5c04\u5f8c\u3001\u7167\u5c04\u90e8\u4f4d\u4ee5\u5916\u306b\u7167\u5c04\u306e\u5f71\u97ff\u304c\u73fe\u308c\u308b\u73fe\u8c61\uff09\u306e\u3053\u3068\u3092\u8a71\u3055\u308c\u307e\u3057\u305f\u3002\u653e\u5c04\u7dda\u306b\u3088\u308b\u7d30\u80de\u6b7b\u306b\u3088\u3063\u3066\u816b\u760d\u6297\u539f\u304c\u4f5c\u3089\u308cCTL\u306b\u63d0\u793a\u3055\u308c\u3001\u514d\u75ab\u53cd\u5fdc\u304c\u8d77\u3053\u308a\u307e\u3059\u3002\u6297CTLA4\u6297\u4f53\u3092\u4f75\u7528\u3057\u3066CTL\u306e\u6297\u816b\u760d\u52b9\u679c\u3092\u9ad8\u3081\u308b\u3068\u3044\u3046\u3053\u3068\u306e\u69d8\u3067\u3059\u3002\u30e1\u30e9\u30ce\u30fc\u30de\u3067\u306f\u3001\u300cImmunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012;\u3000366(10):925-31.\u300d\u3067ipilimumab\u3068\u653e\u5c04\u7dda\u3067\u5b9f\u969b\u306babscopal effect\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002\u30d2\u30c8\u80ba\u764c\u3067\u3082\u300cAn abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res. 2013 Dec;1(6):365-72.\u300d\u304c\u3042\u308a\u307e\u3059\u3002\u3064\u3044\u6700\u8fd1\u3067\u306f\u3001\u300cTGF&beta; Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity. Cancer Res. 2015 Jun 1;75(11):2232-42.\u300d\u304c\u3067\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u653e\u5c04\u7dda\u6cbb\u7642\uff0bTGF&beta;\u306e\u30d6\u30ed\u30c3\u30af\uff0b\u6297PD-1\u6297\u4f53\u3067\u30cd\u30ba\u30df\u306e\u751f\u5b58\u3092\u5ef6\u3070\u3057\u3066\u3044\u307e\u3057\u305f\u3002chemoRT\u3067\u653e\u5c04\u7dda\u80ba\u708e\u304c\u5f37\u3044\u75c7\u4f8b\u306f\u3001\u3044\u3063\u305f\u3093\u5bdb\u89e3\u306b\u306f\u3044\u308b\u3068\u518d\u767a\u3057\u306b\u304f\u3044\u3068\u3044\u3046\u5370\u8c61\u304c\u3042\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u3053\u308c\u3082abscopal effect\u3068\u95a2\u4fc2\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002<br \/>\n<img decoding=\"async\" alt=\"\u5c71\u6839\u53e3\u6f14\" class=\"pict\" height=\"123\" src=\"http:\/\/img-cdn.jg.jugem.jp\/0db\/2419030\/20150718_3691624.jpg\" width=\"165\" \/><br \/>\n&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2\u65e5\u76ee\u306eJSMO\u3067\u3059\u3002\u671d\u4e00\u306e\u300c\u4eba\u3092\u5bfe\u8c61\u3068\u3059\u308b\u533b\u5b66\u7814\u7a76\u306b\u5bfe\u3059\u308b\u502b\u7406\u6307\u91dd\u300d\u306e\u6559\u80b2\u8b1b\u6f14\u3092\u805e\u304d\u307e\u3057\u305f\u3002\u9662\u5185\u3060\u3051\u306eretrospective\u306adata\u89e3\u6790\u3082IRB\u306b\u51fa\u3055\u306a\u304f\u3066\u306f\u3044\u3051\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u304c\u3088\u304f\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u6b21\u306f\u3001\u5c71\u6839\u5148\u751f\u306e [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2281,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","footnotes":""},"categories":[10],"tags":[],"class_list":["post-807","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-10"],"_links":{"self":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=807"}],"version-history":[{"count":0,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/807\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/media\/2281"}],"wp:attachment":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}