{"id":991,"date":"2016-02-12T23:59:00","date_gmt":"2016-02-12T14:59:00","guid":{"rendered":"http:\/\/kawasaki-gim4.main.jp\/wp-gim4web\/?p=991"},"modified":"2016-02-12T23:59:00","modified_gmt":"2016-02-12T14:59:00","slug":"ror1-2","status":"publish","type":"post","link":"https:\/\/kawasaki-gim4.main.jp\/?p=991","title":{"rendered":"ROR1"},"content":{"rendered":"<p>\u4eca\u65e5\u306e\u6284\u8aad\u4f1a\u306f\u3001\u79c1\u304c\u300cROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun. 2016 Jan 4;7:10060.\u300d\u3092\u8aad\u307f\u307e\u3057\u305f\u3002\u540d\u53e4\u5c4b\u5927\u5b66\u306e\u5c71\u53e3\u5148\u751f\u3001\u9ad8\u6a4b\u9686\u5148\u751f\u305f\u3061\u306e\u7d20\u6674\u3089\u3057\u3044\u8ad6\u6587\u3067\u3059\u3002\u79c1\u3069\u3082\u3082\u6570\u5e74\u524d\u304b\u3089\u53d6\u308a\u7d44\u3093\u3067\u3044\u305f\u8ab2\u984c\u3067\u3059\u304c\u3001\u306a\u304b\u306a\u304b\u4e0a\u624b\u304f\u3044\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002ROR1\u3084\u305d\u306e\u8db3\u5834\u30bf\u30f3\u30d1\u30af\u8cea\u306ecavin-1\u304a\u3088\u3073CAV1\u306esiRNA\u3092\u7528\u3044\u3066EGFR-TKI\u8010\u6027\u306e\u3042\u3089\u3086\u308b\u30d0\u30a4\u30d1\u30b9\u30b7\u30b0\u30ca\u30eb\u3092\u514b\u670d\u3057\u305f\u3068\u3044\u3046\u5185\u5bb9\u3067\u3059\u3002ROR1\u3001cavin-1\u3042\u308b\u3044\u306fCAV1\u306eknockdown\u306f\u3001EGF\u3001HGF\u3001IGF-I\u3001IGF-II\u3001Insulin\u3001PDGF\u306b\u3088\u308b\u523a\u6fc0\u306b\u3088\u308b\u305d\u308c\u305e\u308c\u306e\u53d7\u5bb9\u4f53\u3092\u6291\u5236\u3057\u3066pAKT\u3092\u843d\u3068\u3057\u3001\u7d30\u80de\u5897\u6b96\u3092\u6291\u3048\u3066\u3044\u307e\u3057\u305f\u3002\u30ab\u30d9\u30aa\u30e9\u5f62\u6210\u306bcavin-1\u304a\u3088\u3073CAV1\u3092\u7d30\u80de\u819c\u306b\u30ea\u30af\u30eb\u30fc\u30c8\u3059\u308b\u305f\u3081\u306bROR1\u304c\u5fc5\u8981\u306a\u3053\u3068\u3092\u767a\u898b\u3057\u3066\u3044\u307e\u3057\u305f\u3002supplemental figure\u3067\u307b\u3068\u3093\u3069\u306eWestern blotting\u306e\u751fdata\u3092\u51fa\u3057\u3066\u3044\u305f\u306e\u306b\u3082\u3073\u3063\u304f\u308a\u3057\u307e\u3057\u305f\u3002<br \/>\n&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u65e5\u306e\u6284\u8aad\u4f1a\u306f\u3001\u79c1\u304c\u300cROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2280,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","footnotes":""},"categories":[11],"tags":[],"class_list":["post-991","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-journal-club"],"_links":{"self":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=991"}],"version-history":[{"count":0,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/posts\/991\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=\/wp\/v2\/media\/2280"}],"wp:attachment":[{"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kawasaki-gim4.main.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}